Relative sensitivities of DCE-MRI pharmacokinetic parameters to arterial input function (AIF) scaling
نویسندگان
چکیده
منابع مشابه
Tumor Arterial Input Function (AIF) estimation in DCE-MRI studies using a multiple reference tissue method
C. Yang, W. M. Stadler, M. Medved, G. S. Karczmar University of Chicago, Chicago, IL, United States Introduction: Accurate estimation of the arterial input function (AIF) is essential for quantitative analysis of DCE-MRI data. We have previously demonstrated that a common AIF can be estimated from the contrast agent concentration versus time curves (Ct(t)) in two reference tissues with differen...
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Introduction: Quantitative determination of tissue perfusion, permeability and blood volume fraction applying DCE-MRI requires knowledge of the arterial plasma concentration of the contrast agent (CA) in the vessels feeding the tissue of interest. This arterial input function (AIF) must be sampled with high temporal and spatial resolution to enable stable pharmacokinetic (PK) modeling [1]. With...
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L. J. Bains, J. H. Naish, and D. L. Buckley Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, University of Manchester, Manchester, Greater Manchester, United Kingdom, University of Manchester Biomedical Imaging Institute, University of Manchester, Manchester, Greater Manchester, United Kingdom, Division of Medical Physics, University of Leeds, Leeds, United Kin...
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Purpose: The aim of this study was to investigate parameters of the aortic input function (AIF) in dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) of the kidney and its effect on renal functional parameters (perfusion and glomerular filtration rate) calculated using a two-compartment model analysis. Inter-observer agreement, effect of size of region of interest (ROI) in the aor...
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ژورنال
عنوان ژورنال: Journal of Magnetic Resonance
سال: 2016
ISSN: 1090-7807
DOI: 10.1016/j.jmr.2016.05.018